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51.
Metal–Organic Frameworks: Biomimetic Replication of Microscopic Metal–Organic Framework Patterns Using Printed Protein Patterns (Adv. Mater. 45/2015) 下载免费PDF全文
52.
Claudio Modena Giovanni Tecchio Francesca da Porto Marco Donà Paolo Zampieri 《Structure and Infrastructure Engineering》2015,11(4):415-442
In recent years, appraisal of the condition and rehabilitation of existing bridges has become an ongoing problem for bridge owners and administrators in all developed countries. Reliable methodologies are therefore needed in the assessment and retrofit design phases, to identify the vulnerability of each bridge class. The specific problems of common arch bridge types are discussed herein, for both reinforced concrete and masonry structures, proper interventions for their static and seismic retrofitting are illustrated and several examples of applications are provided. Retrofitting is usually coupled with functional refurbishment, according to a methodological approach that takes into account bridge characteristics, state of maintenance and functional requirements, and environmental aspects connected with repair and strengthening systems. 相似文献
53.
Kenneth S. Asiagbe Marco Colombo Michael Fairweather Derrick O. Njobuenwu 《American Institute of Chemical Engineers》2020,66(11):e17017
The flow of dispersed microbubbles was studied with an Eulerian–Lagrangian technique using large eddy simulation to predict the continuous liquid flow and Lagrangian tracking to compute bubble trajectories. The model fully accounts for bubble coalescence and breakup and was applied to horizontal and vertical channel flows. With low levels of turbulence, gravity in horizontal, and lift in vertical, channel flows govern the bubble spatial and collision distribution. When turbulence is sufficiently high to, at least partially, oppose bubble preferential concentration, more uniform collision and coalescence distributions are found, although these remain peaked near the wall in both configurations. Almost 100% coalescence efficiency was always found, due to bubbles colliding along similar trajectories, with breakup only recorded in a flow of low surface tension refrigerant R134a. Models like this can provide the required quantitative understanding of the microbubbles complex behavior, as well as supporting the development of more macroscopic modeling closures. 相似文献
54.
Camilla Costa Renzo Di Felice Paolo Moretti Maddalena Oliva Rouzbeh Ramezani 《加拿大化工杂志》2020,98(12):2516-2529
This work is a companion to a previous article, Part I, published in The Canadian Journal of Chemical Engineering, dealing with CO2 absorption in aqueous solutions containing a single aminic reagent (specifically methyldiethanolamine (MDEA) or piperazine (PZ)). In this second part, different PZ/MDEA mixtures are experimentally studied and their performances are compared with that of the single reagents. It is indeed well known that small quantities of PZ added to MDEA aqueous solutions are sufficient to obtain a significant improvement in the kinetics of the process. PZ is considered an activator or promoter for MDEA, but the mechanism of this synergy has still not been clearly demonstrated. The aim of this study is an attempt to understand how PZ and MDEA can interact by experimentally analyzing this beneficial mutual effect and by explaining it with the help of a suitable yet not complex model. We believe that the involved chemistry is not more complex than that reported in Part I for the single reagents. According to our findings, it is MDEA that enhances the action of PZ, as opposed to what many authors claim. Moreover, our results seem to rule out the existence of any PZ shuttle effect. 相似文献
55.
Francesco Paolo Fiorentino Irene Marchesi Christoph Schrder Ronny Schmidt Jun Yokota Luigi Bagella 《International journal of molecular sciences》2020,21(24)
Small cell lung cancer (SCLC) is an aggressive type of lung cancer with high mortality that is caused by frequent relapses and acquired resistance. Despite that several target-based approaches with potential therapeutic impact on SCLC have been identified, numerous targeted drugs have not been successful in providing improvements in cancer patients when used as single agents. A combination of targeted therapies could be a strategy to induce maximum lethal effects on cancer cells. As a starting point in the development of new drug combination strategies for the treatment of SCLC, we performed a mid-throughput screening assay by treating a panel of SCLC cell lines with BETi or AKi in combination with PARPi or EZH2i. We observed drug synergy between I-BET762 and Talazoparib, BETi and PARPi, respectively, in SCLC cells. Combinatorial efficacy was observed in MYCs-amplified and MYCs-wt SCLC cells over SCLC cells with impaired MYC signaling pathway or non-tumor cells. We indicate that drug synergy between I-BET762 and Talazoparib is associated with the attenuation HR-DSBR process and the downregulation of various players of DNA damage response by BET inhibition, such as CHEK2, PTEN, NBN, and FANCC. Our results provide a rationale for the development of new combinatorial strategies for the treatment of SCLC. 相似文献
56.
Federico Pallottino Alessio Cimini Corrado Costa Francesca Antonucci Paolo Menesatti Mauro Moresi 《Journal of the Institute of Brewing》2020,126(4):394-405
Over the last 80 years, malting and brewing has evolved through increased scientific understanding, driven by numerous factors including efficiency improvement, cost reduction, quality enhancement, risk minimisation, brand marketing and image enhancement. The aim of this work was to review the historical trends in global brewing research in order to identify current opportunities and emerging trends, as well as uncover future key drivers. A bibliometric analysis was performed with English language peer reviewed literature from the Scopus database together with mapping using the VOSviewer clustering software. The bibliometric results were structured to identify which affiliations, authors, and journals have been involved in brewing research, as well as the average number of citations per paper. The bibliometric mapping yielded ‘research term maps’, where the words occurring more frequently in the research papers were grouped in coloured clusters by area of interest, and their relationships indicated. The year maps revealed which average terms tended to emerge in chronological order. The estimated average citation number per paper was about nine. Countries, including Spain, Czech Republic, Italy and Belgium displayed higher average citation scores than the world average. In the period 1940-79, brewing publications were mainly process oriented whereas between 2008-18, there was a shift in focus to the consumer (health and social responsibility) and to environmental sustainability. © 2020 The Institute of Brewing & Distilling 相似文献
57.
David Castells-Quintana Vicente Royuela Paolo Veneri 《Papers in Regional Science》2020,99(4):1045-1064
As cities grow, both the productivity of their inhabitants and the income distribution among them is expected to change. While the empirical literature has widely shown how productivity (and income) changes with city size, the empirical evidence on the effects on income inequality remains very limited. The few papers that study the relationship between city size and city-level inequality focus on a single country and do not provide international comparative evidence. In this paper, we study the relationship between city size and income inequality at city level for a sample of 153 functional urban areas (FUAs) across 11 OECD countries. 相似文献
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